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Related Experiment Videos

Immunological challenge causes mitogenic stimulation in normal connective tissue cells.

L Franzén, K Norrby

    Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology
    |September 1, 1982
    PubMed
    Summary

    Immunological challenges trigger mast cell secretion, leading to significant cell proliferation in adjacent tissues. This contrasts with polyamine-induced mast cell responses, suggesting different mechanisms drive tissue regeneration.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Histology

    Background:

    • Mast cell secretion, triggered by polyamines, is known to induce mitogenesis in surrounding rat mesentery cells.
    • The role of mast cell mediators in tissue proliferation following immunological challenges requires further investigation.

    Purpose of the Study:

    • To investigate whether an immunological challenge, known to induce mast cell secretion, also causes mitogenesis in adjacent normal tissue cells in guinea pigs and rats.
    • To compare the mitogenic effects of mast cell products released during immunological challenges versus polyamine-induced responses.

    Main Methods:

    • Pre-sensitized guinea pigs and rats were challenged with an intraperitoneal antigen injection.
    • Mast cell secretion was quantified by measuring histamine release.

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  • Tissue proliferation was assessed by estimating DNA synthesis and mitotic index in the mesentery.

    • Main Results:

    • An immunological challenge in both species led to significant mast cell histamine release.
    • This histamine release was followed by a marked mitogenic response in mesenteric fibroblasts and mesothelial cells.
    • The quantitative role of primary mast cell products appears different in immunologically induced mitogenesis compared to polyamine-induced mitogenesis.

    Conclusions:

    • Immunological challenges that induce mast cell secretion also stimulate proliferation in adjacent mesenteric cells.
    • The mechanisms underlying mast cell-mediated mitogenesis differ between immunological challenges and polyamine induction.