Combined interaction of antiherpes substances and interferon beta on the multiplication of herpes simplex virus

The inhibition of herpes simplex virus type 1 (strain McIntyre) by two anti-herpes substances applied in combination was studied by means of a CPE inhibition method In Vero cell microcultures. The following substances were studied: AraA monophosphate, thymine arabinoside, ethyldeoxyuridine, acycloguanosine (acyclovir). 3-fluorothymidine, phosphonoformic acid. Most substance pairs showed a moderate degree of synergism. Two additive interactions and one case of antagonism was observed. Human fibroblast interferon, combined with the antiherpes substances, showed an additive interaction with AraAMP, but synergism with the others.