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Bladder outflow obstruction treated with phenoxybenzamine.

P H Abrams, P J Shah, R Stone

British Journal of Urology

|October 1, 1982

Summary

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Phenoxybenzamine (PBZ) significantly improved symptoms of bladder outflow obstruction, including slow stream and hesitancy. This alpha-blocker reduced urethral pressure and is a viable option for managing obstruction, particularly when surgery is delayed.

Area of Science:

Urology
Pharmacology

Background:

Bladder outflow obstruction is a common condition in men.
Pharmacological interventions are sought to manage symptoms and delay surgical options.

Purpose of the Study:

To evaluate the efficacy and safety of phenoxybenzamine (PBZ) in male patients with urodynamically proven bladder outflow obstruction.

Main Methods:

A double-blind, placebo-controlled study involving 41 male patients.
Assessment of symptomatic improvement and urethral pressure profile changes.
Monitoring of side effects.

Main Results:

Overall symptomatic improvement observed in the PBZ group.
Significant reduction in slow stream and hesitancy symptoms.

Related Experiment Videos

Decreased prostatic plateau height and area on urethral pressure profile.

Dizziness was the most common side effect, generally well-tolerated.

Conclusions:

Phenoxybenzamine effectively reduces pressure in the proximal urethra, addressing bladder outflow obstruction.
PBZ is a valuable therapeutic option for managing symptoms of bladder outflow obstruction, especially when delaying surgery.