Aberrant secretors in donors and patients with duodenal ulcer

Results of the screening of aberrant (paradoxal) secretors in 14372 healthy donors and 614 patients with ulcus duodeni are presented. An extremely high frequency of aberrant secretors was established (12.6%) in patients with ulcus duodeni in comparison to donors (0.10%). A new type of aberrant secretors was registered in patients of A1 and A1B blood groups. Their salivas normally inhibited anti-A sera, but the expected inhibition of anti-A1 reagents (dolichos biflorus) could not be observed. The data of comparative quantitative investigations of the inhibiting strength of the ABH antigen in salivas of normal secretors, nonsecretors and aberrant secretors are presented. Various theoretical explanations of aberrant secretors are discussed.