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Regulation of concanavalin A-activated suppressor cell activity by interferon
The Journal of Rheumatology
|September 1, 1982
Summary
Interferon (IF) does not affect the suppressor activity of concanavalin A (Con A)-activated cells. This study found that IF, despite its known immunoregulatory roles, did not alter Con A-activated suppressor cell function.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- Interferon (IF) exhibits broad immunoregulatory effects beyond antiviral activity.
- Interferon is produced by concanavalin A (Con A)-activated suppressor cells.
- A potential role for IF in modulating suppressor cell activity has been hypothesized.
Purpose of the Study:
- To investigate the impact of interferon treatment on the suppressor activity of Con A-activated cells.
- To determine if interferon can modulate the immunoregulatory function of Con A-activated suppressor cells.
Main Methods:
- Concanavalin A (Con A)-activated suppressor cells were treated with varying concentrations of lymphoblastoid or leukocyte interferon (IF).
- The mitogenic response to Con A was assessed in the presence of interferon-treated Con A-activated suppressor cells.
Main Results:
- Con A-activated suppressor cells demonstrated resistance to interferon treatment.
- No significant alteration in the suppressor activity of Con A-activated cells was observed following exposure to interferon concentrations ranging from 1-1000 U/ml.
Conclusions:
- Interferon does not appear to modulate the suppressor activity of Con A-activated suppressor cells.
- The immunoregulatory effects of interferon may not extend to altering the function of these specific suppressor cell populations.