Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Smokers' polycythemia.

J R Smith, S A Landaw

    The New England Journal of Medicine
    |January 5, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Smokers with high hematocrit often have elevated carboxyhemoglobin levels, indicating carbon monoxide exposure. Reducing smoking can reverse these blood volume changes and improve symptoms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A role for methotrexate in the management of non-infectious orbital inflammatory disease.

    The British journal of ophthalmology·2001
    Same author

    Molecular basis for impaired muscle differentiation in myotonic dystrophy.

    Molecular and cellular biology·2001
    Same author

    Atomic force microscopy imaging of fragments from the Martian meteorite ALH84001.

    Journal of microscopy·2001
    Same author

    Chronic hepatitis C: implications for the primary care clinician.

    JAAPA : official journal of the American Academy of Physician Assistants·2001
    Same author

    Effects of combining public assistance and employment on mothers and their young children.

    Women & health·2001
    Same author

    Nodular anterior scleritis associated with ocular trauma.

    Singapore medical journal·2001
    Same journal

    Sparganosis.

    The New England journal of medicine·2026
    Same journal

    Caring for an Aging America - The Looming Crisis of the Long-Term-Care Workforce.

    The New England journal of medicine·2026
    Same journal

    For Those Left Behind.

    The New England journal of medicine·2026
    Same journal

    Colliding Forces - The Aging of the Baby Boom Generation and Contracting Nursing-Home Supply.

    The New England journal of medicine·2026
    Same journal

    Mandated State-Level Surveillance of Assisted Reproductive Technology - An Emerging Threat in the United States.

    The New England journal of medicine·2026
    Same journal

    Ebola at 50 - Lessons for Outbreak Response and Preparedness.

    The New England journal of medicine·2026
    See all related articles

    Area of Science:

    • Hematology
    • Toxicology
    • Pulmonary Medicine

    Background:

    • Smokers often exhibit elevated hematocrit levels.
    • Carbon monoxide exposure from smoking can impact oxygen transport.
    • Polycythemia in smokers requires thorough evaluation.

    Purpose of the Study:

    • To investigate the relationship between smoking, carboxyhemoglobin levels, and blood volume.
    • To assess the effects of carbon monoxide on oxygen-hemoglobin dissociation.
    • To determine the clinical significance of carboxyhemoglobin measurement in polycythemic smokers.

    Main Methods:

    • Recruited 22 smokers with elevated hematocrits.
    • Measured blood carboxyhemoglobin levels and oxygen-hemoglobin dissociation curve (P50).
    • Assessed red-cell volume and plasma volume; monitored symptoms and changes after smoking reduction.

    Related Experiment Videos

    Main Results:

    • Elevated carboxyhemoglobin (mean 11.6%) and left-shifted oxygen-hemoglobin dissociation curve (mean P50 21.6 torr) were observed.
    • Increased red-cell volume and/or reduced plasma volume were common findings.
    • Symptom resolution and normalization of blood volumes occurred in patients who reduced smoking.

    Conclusions:

    • Carbon monoxide from smoking is a frequent cause of elevated red-cell volume or reduced plasma volume.
    • Carboxyhemoglobin measurement is crucial for evaluating polycythemia in smokers.
    • Reducing smoking can effectively reverse smoking-induced hematological changes.