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Portable microcomputer software for nucleotide sequence analysis.

B Fristensky, J Lis, R Wu

    Nucleic Acids Research
    |October 25, 1982
    PubMed
    Summary
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    This study introduces a microcomputer software package for convenient and affordable DNA and RNA sequence analysis. It offers advanced features like sequence translation and homology searches, enhancing bioinformatics research on personal computers.

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Molecular Biology

    Background:

    • Traditional nucleotide sequence data analysis is often performed on expensive, large time-sharing systems.
    • Microcomputers offer a more accessible platform, but often lack sophisticated analysis capabilities.

    Purpose of the Study:

    • To present a package of computer programs for DNA and RNA sequence data analysis on microcomputers.
    • To overcome microcomputer limitations while providing features comparable to large computer programs.

    Main Methods:

    • Development of a software package in Standard Pascal for microcomputers (Apple II).
    • Implementation of features including sequence numbering, translation, restriction site analysis, homology searches (dot-matrix plots), nucleotide distribution analysis, and graphic data display.

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    Main Results:

    • The software package enables convenient and inexpensive analysis of nucleotide sequences on microcomputers.
    • It successfully replicates many features of programs typically found on larger computing systems.
    • Programs are designed for portability across various computer architectures.

    Conclusions:

    • Microcomputers can be effectively utilized for comprehensive DNA and RNA sequence analysis.
    • This software package enhances the accessibility and affordability of advanced bioinformatics tools.
    • The portability of the programs facilitates wider adoption in research settings.