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Interferons: chemical properties.

K H Fantes

    Texas Reports on Biology and Medicine
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Human interferons (IFNs) share similarities, suggesting a common ancestral gene. Research explores their sequences, genetic engineering, and chemical properties, including glycosylation and amino acid composition.

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    Area of Science:

    • Molecular Biology
    • Immunology
    • Biochemistry

    Background:

    • Human interferon-alpha (HuIFN-alpha) comprises a family of 8-10 related components.
    • Amino acid and nucleotide sequences of HuIFN-alpha show similarities to Human interferon-beta (HuIFN-beta) and murine interferons (MuIFN).

    Purpose of the Study:

    • To investigate the evolutionary origins of mammalian interferons.
    • To explore the production and chemical characteristics of human interferons.

    Main Methods:

    • Sequence analysis of amino acid and nucleotide data.
    • Genetic engineering techniques for interferon production in E. coli.
    • Analysis of amino acid composition and glycosylation.

    Main Results:

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    • Evidence suggests a common ancestral gene for all mammalian interferons.
    • Human beta- and some alpha-interferons are producible via genetic engineering.
    • Interferons exhibit high hydrophobic amino acid content; some are glycosylated.

    Conclusions:

    • Mammalian interferons likely evolved from a shared ancestral gene.
    • Further research is needed on the chemistry of gamma-interferon species.