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Immunologic changes in acute canine blastomycosis.

A M Legendre, P U Becker

American Journal of Veterinary Research

|November 1, 1982

Summary

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Canine blastomycosis alters immune responses, showing increased globulins and decreased lymphocyte reactivity. These immunologic changes suggest a role in disease development for affected dogs.

Area of Science:

Veterinary Immunology
Canine Infectious Diseases

Background:

Blastomycosis is a systemic fungal infection in dogs.
Immunologic dysfunction may influence disease severity and outcome.

Purpose of the Study:

To investigate immunologic alterations in dogs with acute blastomycosis.
To assess cell-mediated immunity and serum protein profiles.

Main Methods:

Serum protein electrophoresis and immunoglobulin quantification were performed.
Lymphocyte proliferation assays were conducted using pokeweed, concanavalin A, and phytohemagglutinin.

Main Results:

Dogs showed elevated alpha 2-, beta-, and gamma-globulins, with decreased albumin.
Serum immunoglobulin G was increased, while immunoglobulin M was decreased.

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Significant reductions in lymphocyte reactivity were observed, with 40% of dogs exhibiting lymphopenia.

Conclusions:

Acute blastomycosis induces significant changes in humoral and cellular immunity in dogs.
Impaired lymphocyte function and lymphopenia may contribute to the pathogenesis of canine blastomycosis.