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Lysine transfer RNA2 is the major target for L-ethionine in the rat
Biochemistry
|January 10, 1978
Abstract:
Ethionine, a hepatocarcinogen, ethylates macromolecules in vivo especially tRNA of rat liver. When rats were injected with L-[ethyl-3H]ethionine, the tRNA fraction of the liver was found to be labeled. One tRNA with the highest specific activity was purified and identified as lysine-tRNA2.