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Related Experiment Videos

Screening for spinal defects.

J E Haddow

    Hospital Practice (Office Ed.)
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Second-trimester screening for open neural tube defects is now feasible. Alpha fetoprotein (AFP) testing in maternal serum and amniotic fluid aids diagnosis, improving prenatal care.

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    Area of Science:

    • Prenatal diagnosis
    • Biochemistry
    • Medical screening

    Background:

    • Open neural tube defects (ONTDs) are significant congenital anomalies.
    • Advances in biochemical analysis have enabled improved prenatal detection.
    • Second-trimester screening has become a critical component of modern obstetrics.

    Purpose of the Study:

    • To review the biochemical basis of alpha fetoprotein (AFP) testing for ONTDs.
    • To summarize clinical findings supporting AFP screening in the second trimester.
    • To highlight the feasibility of diagnosing ONTDs through a two-stage screening program.

    Main Methods:

    • Maternal serum alpha fetoprotein (AFP) analysis for initial screening.
    • Amniotic fluid AFP analysis for diagnostic confirmation.

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  • Review of clinical studies on the efficacy of AFP-based screening.

    • Main Results:

    • Second-trimester diagnosis of most ONTDs is now clinically achievable.
    • Maternal serum AFP levels effectively identify high-risk pregnancies.
    • Amniotic fluid AFP levels provide diagnostic accuracy for ONTDs.

    Conclusions:

    • AFP testing is a reliable two-stage screening method for ONTDs.
    • Second-trimester diagnosis of ONTDs is clinically feasible and impactful.
    • Biochemical markers like AFP are crucial for prenatal diagnostic programs.