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Gene(s) affecting the expression of Qa-1.

T H Stanton, S Carbon

    Immunogenetics
    |January 1, 1982
    PubMed
    Summary

    Lymphocyte Qa1 locus expression varies between mouse strains, with H-2Dk strains showing reduced antigen detection. This difference is genetically controlled and linked to specific chromosome regions.

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    Area of Science:

    • Immunogenetics
    • Cellular immunology
    • Molecular genetics

    Background:

    • The Qa1 locus encodes antigenic determinants on lymphocytes, influencing immune responses.
    • Variations in Qa1 expression exist among different mouse strains, impacting cellular interactions.

    Purpose of the Study:

    • To investigate the genetic basis for differential expression of Qa1 antigenic determinants.
    • To identify the chromosomal location of genes controlling Qa1 expression variability.

    Main Methods:

    • Antibody-mediated cytotoxic tests were used to assess lymphocyte lysis.
    • Antisera absorption assays were performed to measure anti-Qa1 activity.
    • Subcellular fractions and mitogen-activated lymphocytes were analyzed.

    Main Results:

    • Lymphocytes from strains with H-2Dk exhibited lower lysis in cytotoxic tests.
    • These cells showed incomplete absorption of anti-Qa1 activity.
    • Unexpressed determinants were found in subcellular fractions of unactivated cells and on activated lymphocytes.

    Conclusions:

    • A genetically controlled phenomenon underlies differential Qa1 expression.
    • The responsible gene(s) are dominant and map to a region between H-2S and Tla loci.

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