An immunologic hypotheses concerning some congenital diseases and malformations

Congenital diseases such as hyaline membrane disease perhaps may come about by transplacental passage of high titred IgG anti HLA antibodies to a fetal pulmonary tissue. Conceivably transplacental passage of high titred anti HLA antibodies (or as yet unidentified antibodies) may interfere with development of tissues at any stage of embryonic and fetal development where the HLA antigen (or other antigen) are present.