Intranasal beclomethasone: mode of action in nasal allergy

The mode of action of topical steroid therapy was investigated in connection with the effects of beclomethasone nasal spray on the three important factors in allergic nasal manifestation: 1) the number of basophilic cells (blood basophils and tissue mast cells) in the nasal mucosa, 2) the sensitivity of the basophilic cells to allergen and 3) the mucosal sensitivity to histamine. The results indicated that of the three factors the inhibition in the accumulation of basophilic cells in the mucosal surface was the most important mode of action of beclomethasone nasal spray.