Axonal transport of nerve growth factor and serum albumin in the dystrophic mouse

Specific (nerve growth factor, NGF) and non-specific (serum albumin, BSA) uptake followed by retrograde axonal transport was studied in the sciatic nerves of normal (C57BL/6J) and dystrophic (dy2J/dy2J) mice. In the dystrophic mouse there was a significant decrease in the amount of NGF transported to dorsal root ganglia or BSA accumulating at a ligature placed on the sciatic nerve.