Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of GABA in the cerebrospinal fluid of patients with progressive myoclonus epilepsy and its correlation with

E M Airaksinen, E Leino

    Acta Neurologica Scandinavica
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Whiplash injuries in Finland: a prospective 1-year follow-up study.

    Clinical and experimental rheumatology·2002
    Same author

    A population-based study on epilepsy in mentally retarded children.

    Epilepsia·2000
    Same author

    Vasopressin in the cerebrospinal fluid of febrile children with or without seizures.

    Brain & development·1996
    Same author

    Osmolality and electrolytes in cerebrospinal fluid and serum of febrile children with and without seizures.

    European journal of pediatrics·1996
    Same author

    Low sodium levels in serum are associated with subsequent febrile seizures.

    Acta paediatrica (Oslo, Norway : 1992)·1995
    Same author

    The role of fever on cerebrospinal fluid glucose concentration of children with and without convulsions.

    Acta paediatrica (Oslo, Norway : 1992)·1995
    Same journal

    Editorial.

    Acta neurologica Scandinavica·2022
    Same journal

    Advances in sudden unexpected death in epilepsy.

    Acta neurologica Scandinavica·2022
    Same journal

    Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit.

    Acta neurologica Scandinavica·2022
    Same journal

    Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions.

    Acta neurologica Scandinavica·2022
    Same journal

    Seizure detection based on wearable devices: A review of device, mechanism, and algorithm.

    Acta neurologica Scandinavica·2022
    Same journal

    Walking confidence and perceived locomotion ability explain participation after stroke: A cross-sectional experimental study.

    Acta neurologica Scandinavica·2022
    See all related articles

    This study found significantly lower GABA levels in progressive myoclonus epilepsy (PME) patients compared to controls. These GABA reductions correlated with other neurochemical markers, suggesting potential insights into PME

    Area of Science:

    • Neuroscience
    • Epilepsy Research
    • Biochemistry

    Background:

    • Progressive myoclonus epilepsy (PME) is a hereditary neurological disorder characterized by seizures, myoclonus, and cognitive decline.
    • The exact cause of PME remains unknown, although GABAergic medications are effective treatments.
    • Understanding the underlying neurochemistry is crucial for PME pathogenesis.

    Purpose of the Study:

    • To investigate the concentration of gamma-aminobutyric acid (GABA) in the cerebrospinal fluid (CSF) of PME patients.
    • To compare GABA levels in PME patients with those in sex- and age-matched epileptic controls.
    • To explore correlations between CSF GABA levels and other neurochemical markers (HVA, 5HIAA) in PME.

    Main Methods:

    • Cerebrospinal fluid (CSF) samples were collected from 15 PME patients and control subjects.

    Related Experiment Videos

  • GABA concentrations in CSF were measured using [specific assay method - not provided in abstract].
  • CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA) were analyzed from previous determinations.

    • Main Results:

    • CSF GABA concentrations were statistically significantly lower in PME patients (approximately 75% of control levels).
    • A significant correlation was observed between GABA levels and HVA/5HIAA concentrations in PME patients.
    • No significant correlation between GABA and HVA/5HIAA was found in the epileptic control group.

    Conclusions:

    • The study demonstrates a marked reduction in GABAergic function in PME patients.
    • The observed correlations suggest a potential link between GABAergic deficits and other neurotransmitter systems in PME.
    • Further research is needed to determine if these neurochemical changes are primary causes or secondary consequences of neuronal loss in PME.