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Related Experiment Videos

Dantrolene sodium: effects on smooth muscle.

S Graves, K L Dretchen, G O Kruger

    European Journal of Pharmacology
    |January 1, 1978
    PubMed
    Summary

    Dantrolene sodium irreversibly reduced smooth muscle responses in guinea pig ileum and vas deferens preparations. This effect, likely due to reduced calcium influx, was lessened by increased calcium concentrations.

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    Area of Science:

    • Pharmacology
    • Muscle Physiology

    Background:

    • Dantrolene sodium is known for its effects on skeletal muscle.
    • Its impact on smooth muscle remains less understood.

    Purpose of the Study:

    • To investigate the in vitro effects of dantrolene sodium on smooth muscle.
    • To explore the potential role of calcium in dantrolene's mechanism of action on smooth muscle.

    Main Methods:

    • Utilized guinea pig ileum and vas deferens preparations for in vitro studies.
    • Administered various agonists (acetylcholine, histamine, etc.) and electrical stimulation.
    • Manipulated calcium concentrations in the bathing media.

    Main Results:

    • Dantrolene sodium irreversibly decreased responses to multiple agonists and electrical stimulation in both ileum and vas deferens.
    • Increased extracellular calcium concentrations partially reversed dantrolene's inhibitory effects.
    • Observed a depressant effect of dantrolene on smooth muscle function.

    Conclusions:

    • Dantrolene sodium exhibits inhibitory effects on smooth muscle, similar to its action on skeletal muscle.
    • The mechanism likely involves the inhibition of calcium influx into smooth muscle cells.
    • Calcium availability plays a role in modulating dantrolene's effects on smooth muscle.

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