[Preparation of prothrombin complex concentrates with reduced thrombogenicity]

Thrombogenicity of prothrombin complex concentrates can be diminished by adding heparin to human citrate plasma, preferably before or during the adsorption of the prothrombin complex. Time, extent, and procedure of the heparin addition are dependent on the conditions of the initial material, the realization of the procedure and the provided application of the plasma supernatant after isolating the prothrombin complex. The procedure involves the use of buffer solutions containing heparin and antithrombin III. An activity of a procoagulatory effect cannot be identified in these preparations.