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Coupling between neurons of the developing rat neocortex.

B W Connors, L S Benardo, D A Prince

    The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
    |April 1, 1983
    PubMed
    Summary
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    Neuronal coupling is prevalent in young rats but declines significantly with age. This study quantizes the decrease in neuronal connections during postnatal development.

    Area of Science:

    • Neuroscience
    • Developmental Biology

    Background:

    • Neuronal communication is crucial for brain function.
    • Understanding the developmental trajectory of neuronal connectivity is essential.

    Purpose of the Study:

    • To investigate the prevalence and developmental changes of neuronal coupling in the rat neocortex.
    • To characterize the properties of neuronal coupling during postnatal development.

    Main Methods:

    • Utilized single intracellular injections of the fluorescent dye Lucifer Yellow CH.
    • Assessed dye coupling in neurons across different postnatal ages (1-4 days, 10-18 days, adult).
    • Blocked chemical synaptic activity to analyze electrophysiological properties.

    Main Results:

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  • Dye coupling was observed in 70% of neurons in 1-4 day old rats, decreasing to 20% in adults.
  • The number of coupled neurons per aggregate diminished from 3-7 in young rats to rarely more than two in adults.
  • Electrophysiological recordings in young rats revealed potential electrotonic potentials, absent in adults.

    • Conclusions:

    • Neuronal coupling is extensive in the immature rat neocortex.
    • Coupling significantly declines during postnatal development, preceding the rapid increase in chemical synapses.