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Blood groups and affective disorders.

L Beckman, B Cedergren, C Perris

    Human Heredity
    |January 1, 1978
    PubMed
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    Blood group factor B is more frequent in patients with psychotic affective disorders. Nonpsychotic patients showed an increased frequency of the Kell K(+) phenotype, while the unclassifiable group had less SS phenotype.

    Area of Science:

    • Psychiatry
    • Genetics
    • Immunology

    Background:

    • Affective disorders encompass a range of mood disturbances.
    • Blood group antigens are genetically determined and have been investigated for associations with various diseases.
    • Previous studies suggested links between specific blood types and bipolar disorder, but findings were inconsistent.

    Purpose of the Study:

    • To investigate the frequencies of various blood group systems (ABO, Rh, MNSs, P, Kell, Lewis, Duffy) in patients diagnosed with affective disorders.
    • To determine if specific blood group phenotypes are associated with different subtypes of affective disorders, including bipolar psychosis, unipolar depression, and reactive depression.

    Main Methods:

    • A cohort of 219 patients with affective disorders was analyzed.

    Related Experiment Videos

  • Patients were categorized into four groups: bipolar psychosis, unipolar recurrent depressive psychosis, nonpsychotic reactive depression, and unclassifiable affective disorder.
  • Frequencies of ABO, Rh, MNSs, P, Kell, Lewis, and Duffy blood groups were statistically compared across these patient groups.

    • Main Results:

    • An increased frequency of blood group factor B was observed in psychotic patients (bipolar and unipolar) compared to nonpsychotic patients.
    • A decreased frequency of the SS phenotype (MNSs system) was found in the unclassifiable affective disorder group.
    • An increased frequency of the Kell K(+) phenotype was noted among nonpsychotic patients.

    Conclusions:

    • Blood group factor B may be associated with the pathophysiology of psychotic affective disorders.
    • The Kell K(+) phenotype might be a protective factor or associated with nonpsychotic depression.
    • The study did not confirm previous findings regarding associations between ABO blood types (A and O) and differences between bipolar and unipolar patients.