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Togaviridae.

J S Porterfield, J Casals, M P Chumakov

    Intervirology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    The Togaviridae family comprises four genera of viruses with single-stranded RNA and a lipoprotein envelope. Many of these viruses, including Alphavirus and Flavivirus, are known as arboviruses.

    Area of Science:

    • Virology
    • Molecular Biology

    Background:

    • The Togaviridae family is a significant group of viruses.
    • Understanding their structure and characteristics is crucial for virology research.

    Purpose of the Study:

    • To describe the Togaviridae family, including its genera and key properties.
    • To highlight the structural and genetic features of Togaviridae virions.

    Main Methods:

    • Descriptive analysis of Togaviridae family characteristics.
    • Review of virion composition, including RNA, nucleocapsids, and envelopes.

    Main Results:

    • Togaviridae possess single-stranded, linear RNA (approx. 4x10^6 MW).
    • Virions feature isometric nucleocapsids within a lipoprotein envelope containing host lipids and viral polypeptides, including glycoproteins.

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  • Infectious RNA can be recovered from virions.
  • The family includes at least 80 members, with Alphavirus and most Flavivirus genera classified as arboviruses.

    • Conclusions:

    • The Togaviridae family is characterized by specific structural and genetic features.
    • The classification of many Togaviridae members as arboviruses has significant epidemiological implications.