Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Gas embolism in the rat].

D Lagneaux, L Bodson, R Remacle

    Archives Internationales De Physiologie Et De Biochimie
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Gaseous carbon dioxide (CO2) injection causes pulmonary hypertension and hypotension in rats. Vagotomy prevents apnea and bradycardia but leads to pulmonary edema and death, highlighting the role of vagal reflexes in CO2 embolism response.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Annals of burns and fire disasters·2018
    Same author

    [Blue baby syndrome: the source of the truth].

    Revue medicale de Liege·2014
    Same author

    Effect of L-glutamine for freezing equine embryos: evaluation by DAPI staining and transfer of multiple embryos to recipient mares.

    Journal of reproduction and fertility. Supplement·2010
    Same author

    [The value of mobile intensive care unit (MICU): does it remain to be proven?].

    Revue medicale de Liege·2006
    Same author

    Analysis of PEG 400 and 4000 in urine for gut permeability assessment using solid phase extraction and gel permeation chromatography with refractometric detection.

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2004
    Same author

    Parentage testing of Day 10 equine embryos by amplified PCR analysis of microsatellites.

    Equine veterinary journal. Supplement·1998

    Area of Science:

    • Physiology
    • Cardiovascular Research
    • Respiratory Medicine

    Context:

    • Pulmonary embolism (PE) is a critical condition affecting the cardiopulmonary system.
    • Gaseous carbon dioxide (CO2) can induce experimental PE, offering a model to study physiological responses.
    • The role of vagal nerve reflexes in mediating cardiovascular and respiratory changes during CO2-induced PE is not fully understood.

    Purpose:

    • To investigate the physiological effects of gaseous CO2-induced pulmonary embolism in rats.
    • To determine the influence of vagotomy on the cardiovascular and respiratory responses to CO2 embolism.
    • To elucidate the mechanisms underlying pulmonary hypertension, apnea, bradycardia, and pulmonary edema in this experimental model.

    Summary:

    • Intravenous CO2 injection in anesthetized rats rapidly induced pulmonary hypertension, systemic hypotension, and bradycardia.

    Related Experiment Videos

  • Vagotomy abolished the transient apnea and bradycardia observed in intact rats, suggesting a reflexogenic origin.
  • While intact rats exhibited prolonged pulmonary hypertension and hyperventilation, vagotomized rats developed acute pulmonary edema and succumbed, indicating the protective role of vagal reflexes.
  • The study suggests that prolonged pulmonary hypertension in rats may involve vasospasm beyond mechanical obstruction.
  • Pulmonary edema in vagotomized rats appears linked to hyperinflation, a response also seen with other respiratory challenges.

    • Impact:

    • This research clarifies the critical role of vagal reflexes in mitigating the acute cardiovascular and respiratory consequences of CO2 pulmonary embolism.
    • Findings provide insights into the pathophysiology of PE and potential therapeutic targets, particularly concerning reflex modulation.
    • The study establishes a rat model for investigating PE, differentiating species-specific responses and highlighting the importance of circulatory dynamics and vasospasm.