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Sensitized spleen B-cells in tolerance-resisting SJL mice
Immunology Letters
|January 1, 1983
Abstract:
A subpopulation of B-cells becomes sensitized in the 15-week-old SJL mouse, exposed to aggregate-freed rabbit gamma-globulin, which is highly tolerogenic when given to younger animals. This state of activation can only be expressed in collaboration with sensitized T-cells. The sensitized B-cell does not play an important role in the response of the intact 15-week-old SJL mouse, since there are no sensitized T-cells in the sRGG-treated animals.