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[Infected wounds].

F W Gierhake

    Langenbecks Archiv Fur Chirurgie
    |January 1, 1982
    PubMed
    Summary

    Continuous antibiotic therapy aims to prevent surgical wound infections but has shown minimal benefits despite reduced side effects. Prophylactic gamma-globulin also lacks proven therapeutic advantages for postoperative wound infections.

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    [Clinical relevancy of cellular immunity in bronchogenic carcinoma].

    Praxis und Klinik der Pneumologie·1982
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    [Immunoglobulins in Surgery (author's transl)].

    Immunitat und Infektion·1981
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    [Antibiotics -- therapy or prophylaxis?].

    Aktuelle Probleme in Chirurgie und Orthopadie·1981
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    [Indicated and non-indicated administration of antibiotics in surgery (author's transl)].

    Immunitat und Infektion·1978
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    [Hygiene and asepsis in surgery: introduction (author's transl)].

    Langenbecks Archiv fur Chirurgie·1977
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    [Ways to a timely hospital hygiene (author's transl)].

    Immunitat und Infektion·1977

    Area of Science:

    • Infectious Diseases
    • Surgical Site Infections
    • Antimicrobial Therapy

    Context:

    • Surgical wound infections remain a significant concern in healthcare.
    • Continuous prophylactic antibiotic therapy has been a long-standing approach to prevent infection progression.
    • Previous clinical trials reported poor outcomes and frequent side effects with this method.

    Purpose:

    • To evaluate the efficacy of continuous prophylactic antibiotic therapy in preventing surgical wound infections.
    • To assess the therapeutic benefits and side effects of recent prophylactic antibiotic regimens.
    • To examine the effectiveness of prophylactic gamma-globulin in preventing postoperative wound infections.

    Summary:

    • Recent studies indicate that while pre- or perioperative prophylactic antibiotics have minimal side effects, their therapeutic benefits in preventing surgical wound infections are not yet conclusively proven.
    • Similarly, prophylactic gamma-globulin infusion has not demonstrated clear therapeutic advantages for preventing postoperative wound infections.

    Impact:

    • Highlights the need for further research to establish definitive evidence for the prophylactic use of antibiotics and gamma-globulin in surgical settings.
    • Suggests a re-evaluation of current prophylactic strategies for surgical wound infections.
    • Informs clinical decision-making regarding infection prevention in surgical patients.

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