Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Particle arrays in earthworm postjunctional membranes.

J Rosenbluth

    The Journal of Cell Biology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Freeze-fracture analysis of earthworm muscle reveals trough-shaped structures containing particles, likely acetylcholine receptors, within the muscle cell membrane at neuromuscular junctions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rapidly tunable ultrabroadband flying focus using adaptive optics and an axiparabola.

    Optics letters·2026
    Same author

    Structural bases for central nervous system malfunction in the quaking mouse: dysmyelination in a potential model of schizophrenia.

    Journal of neuroscience research·2012
    Same author

    OBLIQUELY STRIATED MUSCLE : IV. Sarcoplasmic Reticulum, Contractile Apparatus, and Endomysium of the Body Muscle of a Polychaete, Glycera, in Relation to Its Speed.

    The Journal of cell biology·2009
    Same author

    Obliquely striated muscle. IV. Sarcoplasmic reticulum, contractile apparatus, and endomysium of the body muscle of a polychaete, Glycera, in relation to its speed.

    The Journal of cell biology·2009
    Same author

    Spinal cord dysmyelination caused by an antiproteolipid protein IgM antibody: implications for the mechanism of central nervous system myelin formation.

    Journal of neuroscience research·2008
    Same author

    Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2006

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Biochemistry

    Background:

    • Neuromuscular junctions are critical for muscle contraction.
    • Cholinergic junctions utilize acetylcholine as a neurotransmitter.
    • Previous studies suggested granular elements in the postjunctional membrane are acetylcholine receptors.

    Purpose of the Study:

    • To analyze the ultrastructure of earthworm muscle cell membranes at neuromuscular junctions.
    • To elucidate the arrangement and structure of putative acetylcholine receptors within the membrane.

    Main Methods:

    • Freeze-fracture electron microscopy of earthworm body wall muscle.
    • Analysis of intramembranous particles and membrane leaflet structures.

    Main Results:

    Related Experiment Videos

    • Distinctive trough-shaped concavities were observed in the protoplasmic leaflet of the muscle cell membrane.
    • These troughs contained diagonally oriented rows of particles, sometimes in ordered arrays.
    • The particle concentration and arrangement corresponded to previously identified granular elements interpreted as acetylcholine receptors.

    Conclusions:

    • Freeze-fracture data provide a detailed view of acetylcholine receptor arrangement in the muscle cell membrane.
    • Putative acetylcholine receptors are organized in ordered arrays within the membrane.
    • These receptors extend into the hydrophobic layer of the membrane.