[Effect of dextran 60,000(D 60) and hydroxyethyl starch 450,000 (HES 450) on lymphocyte transformation]

Lymphocytes of volunteers were recovered, isolated and H3 thymidine incorporation was measured in the presence of D 60 and HES 450 with and without PHA. Without mitogen dextran caused only a marginal increase of incorporation whereas HES brought about no change. When PHA-stimulation was used, both compounds seemed not to influence H3-thymidine incorporation. It is concluded that in vitro even in molar concentrations corresponding to clinical haemodilution these solutions appear not to suppress lymphocytic activity.