Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CNS peptides and glucoregulation.

L A Frohman

    Annual Review of Physiology
    |January 1, 1983
    PubMed
    Summary

    Neuropeptides play a crucial role in blood glucose regulation through neural and paracrine actions, not classical hormones. Understanding their integrative function offers insights into carbohydrate metabolism disorders.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial.

    The Journal of clinical endocrinology and metabolism·2008
    Same author

    Consensus statement: medical management of acromegaly.

    European journal of endocrinology·2005
    Same author

    Diagnosis and treatment of acromegaly complications.

    Journal of endocrinological investigation·2004
    Same author

    Growth hormone-releasing hormone and pituitary somatotrope proliferation.

    Minerva endocrinologica·2003
    Same author

    The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling.

    Endocrinology·2001
    Same author

    The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback.

    Endocrinology·2001

    Area of Science:

    • Neuroendocrinology
    • Metabolic Regulation

    Background:

    • Blood glucose regulation involves complex CNS, hormonal, and neural integration.
    • The precise role of neuropeptides in glucoregulation is not fully understood.
    • Neuropeptides are found in the central and peripheral nervous systems, as well as the gastrointestinal tract and endocrine pancreas.

    Purpose of the Study:

    • To elucidate the role of neuropeptides in the regulation of blood glucose.
    • To explore the mechanisms by which neuropeptides influence glucose metabolism.
    • To identify potential therapeutic targets for carbohydrate metabolism disorders.

    Main Methods:

    • Review of existing literature on neuropeptide function in glucoregulation.
    • Analysis of studies on neuropeptide distribution in the nervous system and endocrine organs.
    • Examination of evidence for paracrine and neurotransmitter actions of neuropeptides.

    Main Results:

    • Neuropeptides are present throughout the autonomic nervous system and in the gut and pancreas.
    • Neuropeptide effects on glucose metabolism are mediated by paracrine or neurotransmitter actions, not systemic hormonal release.
    • Specific neuropeptides, like somatostatin, demonstrate integrative roles in glucose absorption, pancreatic secretion, and hepatic glucose production.

    Conclusions:

    • Neuropeptides are integral components of neural and paracrine mechanisms regulating blood glucose.
    • Further research into neuropeptide interactions and CNS control is needed.
    • Understanding neuropeptide roles can provide new insights into metabolic disorders.

    Related Experiment Videos