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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
Published on: June 29, 2016
Monosaccharides define two immunodominant structures of chicken fetal antigen
Abstract:
Chicken fetal antigen (CFA) is an oncodevelopmental antigen associated with hematolymphoid development and differentiation. The immunodominant structures of two CFA determinants were characterized by hapten inhibition of microcytotoxicity (HIM) and were found to be defined by specific monosaccharides. CFA determinants 5 and 11 were effectively (greater than 50%) inhibited by D-mannose and D-glucose, respectively. Therefore, these carbohydrate residues, or closely related structures, are proposed as the immunodominant structures for these antigenic determinants. Implications of these results vis à vis the developmental control and biological role of CFA are discussed.
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