Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgen receptors.

G D Berkovitz, T R Brown, C J Migeon

    Clinics in Endocrinology and Metabolism
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Structural abnormalities in the androgen receptor cause androgen insensitivity syndrome, affecting cell function and leading to varied physical presentations. This condition results in infertility and is linked to testosterone and LH levels.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Attitudes of adult 46, XY intersex persons to clinical management policies.

    The Journal of urology·2004
    Same author

    Gender assignment in newborns: gender identity/role differentiation in genetic males affected by abnormal sex differentiation.

    Minerva pediatrica·2004
    Same author

    Female phenotype at birth and postnatal masculinization, during the first months of life, associated with transient 5 alpha-reductase 2 deficiency in a preterm infant. A timing defect syndrome?

    Minerva pediatrica·2004
    Same author

    Congenital micropenis: long-term medical, surgical and psychosexual follow-up of individuals raised male or female.

    Hormone research·2002
    Same author

    Absence of mutations involving the LIM homeobox domain gene LHX9 in 46,XY gonadal agenesis and dysgenesis.

    The Journal of clinical endocrinology and metabolism·2001
    Same author

    Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Growth, development, and therapeutic considerations.

    Endocrinology and metabolism clinics of North America·2001
    Same journal

    Long-term complications of diabetes.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic retinopathy: current concepts of evaluation and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic neuropathies and pain.

    Clinics in endocrinology and metabolism·1986
    Same journal

    The diabetic foot: pathophysiology and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Autonomic neuropathy: its diagnosis and prognosis.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Dialysis: continuous ambulatory peritoneal dialysis and haemodialysis.

    Clinics in endocrinology and metabolism·1986
    See all related articles

    Area of Science:

    • Endocrinology
    • Genetics
    • Molecular Biology

    Background:

    • Testosterone and dihydrotestosterone mediate effects via intracellular androgen receptors.
    • Structural abnormalities of the androgen receptor impair cellular androgen action, causing androgen insensitivity syndrome.
    • Androgen insensitivity is classified by completeness and androgen receptor status (AR(+), AR(-), AR(+/-)).

    Purpose of the Study:

    • To describe the classification and clinical spectrum of androgen insensitivity syndrome.
    • To highlight the hormonal profile (normal/high testosterone, elevated LH) in patients.
    • To explore the role of androgen receptor function in benign prostatic hypertrophy and prostate cancer therapy response.

    Main Methods:

    • Classification based on clinical phenotype and androgen receptor (AR) status.

    Related Experiment Videos

  • Hormonal level assessment (testosterone, LH).
  • Investigational studies on AR function in benign prostatic hypertrophy and prostate cancer.

    • Main Results:

    • Patients exhibit normal or high testosterone and elevated serum LH.
    • Complete androgen insensitivity presents as a female phenotype.
    • Partial androgen insensitivity shows variable virilization, from minimal to masculine appearance.
    • All described patients with androgen insensitivity syndrome are infertile.

    Conclusions:

    • Androgen receptor abnormalities are central to androgen insensitivity syndrome.
    • The syndrome presents a spectrum of phenotypes and is consistently associated with infertility.
    • Androgen receptor function is a key area of research for prostate conditions.