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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

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Nonfamilial, vibration-induced angioedema.

S Ting, B E Reimann, D O Rauls

The Journal of Allergy and Clinical Immunology

|June 1, 1983

Summary

Vibratory angioedema, a rare physical reaction, caused prolonged swelling in a teen after vibration exposure. Desensitization therapy successfully eliminated the patient's symptoms.

Area of Science:

Immunology
Dermatology
Allergy

Background:

Vibratory angioedema is a rare physical urticaria.
Characterized by localized swelling triggered by mechanical vibration.

Observation:

A 16-year-old Mexican-American male experienced prolonged hand swelling after vibratory stimulus.
Control subjects and family members showed only transient skin reactions.

Findings:

Vibratory challenge induced rapid plasma histamine fluctuations in the patient.
Histopathology revealed mast cell degranulation and granule fragmentation at the stimulated site.
Prausnitz-Küstner testing was negative, ruling out IgE-mediated allergy.

Implications:

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This case highlights a unique mast cell degranulation mechanism in vibratory angioedema.

Successful desensitization therapy offers a potential treatment strategy for this condition.

Further research into vibratory urticaria mechanisms is warranted.