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Uremic hyperstannum: elevated tissue tin levels associated with uremia.
The Journal of Laboratory and Clinical Medicine
|January 1, 1978
Summary
Uremic patients, both dialyzed and nondialyzed, exhibit elevated tin levels in tissues, suggesting a link between tin accumulation and uremia, not dialysis. This finding highlights potential implications for kidney function and heme oxygenase activity.
Area of Science:
- Biochemistry
- Trace Element Analysis
- Nephrology
Background:
- Previous studies indicated elevated tin concentrations in dialyzed uremic patients.
- The role of tin in uremia and its association with dialysis remained unclear.
Purpose of the Study:
- To investigate tin concentrations in liver and kidney tissues of uremic patients.
- To determine if elevated tin levels are associated with uremia or dialysis treatment.
- To explore the potential significance of tin in kidney function.
Main Methods:
- Postmortem liver tissue samples from 80 individuals (controls, nondialyzed uremic, dialyzed uremic) were analyzed.
- Tin concentrations in liver and kidney tissues were measured.
- Urinary tin excretion was assessed in nondialyzed uremic patients.
Main Results:
- Nondialyzed uremic patients showed significantly elevated liver tin concentrations (approximately three times control levels).
- Abnormally high tin levels were also detected in the kidneys of uremic patients.
- Urinary tin excretion in nondialyzed uremic patients was found to be normal.
Conclusions:
- Elevated tin levels are associated with uremia itself, independent of dialysis.
- The accumulation of tin in uremic kidneys may be significant, given tin's role as an inducer of heme oxygenase.
- Normal urinary tin excretion suggests impaired tissue retention or altered metabolic pathways in uremia.