Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrophysiologic changes induced by external transthoracic countershock.

G J Anderson, J Reiser

    Journal of Electrocardiology
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Alpha heating of indirect-drive layered implosions on the National Ignition Facility.

    Physical review. E·2023
    Same author

    Differential Pathogenicity of Xanthomonas campestris pv. phaseoli and X. fuscans subsp. fuscans Strains on Bean Genotypes with Common Blight Resistance.

    Plant disease·2019
    Same author

    Intestinal Iron Transport and its Regulation.

    Hematology (Amsterdam, Netherlands)·2016
    Same author

    Lupus nephritis: through the looking-glass.

    Lupus·2015
    Same author

    A scalable method to concentrate lentiviral vectors pseudotyped with measles virus glycoproteins.

    Gene therapy·2015
    Same author

    Accurate assessment of systemic iron status in cystic fibrosis will avoid the hazards of inappropriate iron supplementation.

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2012

    Suprathreshold transthoracic shocks can cause significant cardiac electrical disturbances, including arrhythmias like ventricular tachycardia. These shocks lead to cellular injury and altered electrophysiological properties, potentially increasing the risk of dangerous heart rhythms.

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Cardiac Surgery

    Background:

    • Transthoracic shocks are used in critical care settings.
    • Understanding the electrophysiological consequences of these shocks is crucial for patient safety.
    • Previous research has not fully characterized the detailed cellular and functional changes induced by suprathreshold shocks.

    Purpose of the Study:

    • To investigate the electrophysiological effects of suprathreshold transthoracic shocks on cardiac function.
    • To identify specific cellular and functional changes in the heart following these electrical interventions.

    Main Methods:

    • Anesthetized dogs received two consecutive suprathreshold transthoracic shocks (10 joules/kg).
    • Cardiac electrophysiological parameters were assessed immediately post-shock and 48 hours later.

    Related Experiment Videos

  • Histological examination of cardiac tissue was performed to identify cellular injury.

    • Main Results:

    • Ventricular extrasystoles, A-V block, ventricular tachycardia, and asystole were observed acutely.
    • Post-mortem analysis revealed cellular injury, including loss of resting potential and action potential abnormalities.
    • Shortened functional refractory periods, action potential alternans, and conduction delays were identified.
    • Histological findings showed sub-epicardial injury.

    Conclusions:

    • Suprathreshold transthoracic shocks induce significant acute and sub-acute electrophysiological alterations in the heart.
    • These changes, including cellular injury and conduction abnormalities, may predispose the heart to tachyarrhythmias.
    • Further research is needed to optimize shock parameters and mitigate risks.