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Norepinephrine stimulates amylase release from pancreatic acini
The Journal of Surgical Research
|June 1, 1983
Summary
Norepinephrine from the sympathetic nervous system enhances pancreatic enzyme secretion. This effect on amylase release is independent of blood flow changes, suggesting a direct role for the nervous system in digestion.
Area of Science:
- Physiology
- Neuroendocrinology
- Gastroenterology
Background:
- Sympathetic nerve activity influences pancreatic enzyme secretion.
- Previous research could not distinguish direct cellular effects from blood flow alterations.
Purpose of the Study:
- To investigate the direct effect of norepinephrine on pancreatic acinar cells.
- To determine if sympathetic stimulation modulates pancreatic enzyme secretion independently of hemodynamic changes.
Main Methods:
- Utilized an in vitro preparation of dispersed guinea pig pancreatic acini.
- Measured amylase release in response to various pancreatic stimulants and norepinephrine.
Main Results:
- Physiologic concentrations of norepinephrine enhanced amylase release from pancreatic acini.
- This enhancement occurred even with supramaximal cholecystokinin stimulation.
- The effect was observed independent of changes in pancreatic blood flow.
Conclusions:
- The sympathetic nervous system plays a role in modulating pancreatic enzyme secretion.
- Norepinephrine directly influences pancreatic acinar cells to enhance amylase release.
- This mechanism operates independently of sympathetic effects on pancreatic blood flow.