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[Thermogenic shivering in the anesthetized rat]
Archives Internationales De Physiologie Et De Biochimie
|December 1, 1982
Summary
Ketanserine administration in rats caused paw skin warming and decreased core body temperature, inducing shivering below 35°C. This effect is linked to Ketanserine
Area of Science:
- Pharmacology
- Neuroscience
- Physiology
Context:
- Pentobarbital-anesthetized rats were used to investigate the physiological effects of Ketanserine.
- The study focused on thermoregulation and the impact of Ketanserine on body temperature.
- Ketanserine's effects were observed at intravenous doses ranging from 2.5 to 10 mg/kg.
Purpose:
- To determine the effects of Ketanserine on body temperature regulation in rats.
- To investigate the potential mechanism of Ketanserine-induced thermoregulatory changes, specifically shivering.
- To explore the relationship between Ketanserine and central serotonin 5-HT2 receptors.
Summary:
- Ketanserine administration (2.5-10 mg/kg, i.v.) in rats led to an increase in paw skin temperature and a decrease in central body temperature.
- A distinct thermogenetic shivering response was observed when core body temperature dropped below 35°C.
- This shivering is hypothesized to be a characteristic effect of Ketanserine, potentially mediated by its interaction with central 5-HT2 receptors.
Impact:
- Provides insight into the central and peripheral thermoregulatory effects of Ketanserine.
- Suggests a role for 5-HT2 receptor antagonism in modulating body temperature and shivering.
- Highlights Ketanserine as a potential tool for studying serotonergic pathways in thermoregulation.