Lymphomatoid papulosis--electron microscopic observations on two cases

The electron microscopic examination of two cases of lymphomatoid papulosis revealed a mixed cellular infiltrate consisting of lymphoid cells with T-cell features, histiocyte-like cells and some fibroblasts. Furthermore, uncharacteristic mesenchymal cells and some granulocytes could be identified. The activated vascular structures did not contribute cells to the infiltrates. Focal cellular protrusions of lymphocytic cells and close spatial relations between different cell types (especially between lymphocytic and histiocyte-like cells) speak for the action of regulative factors. Possibly nerval elements also influence the proliferative processes. Thus lymphomatoid papulosis can be interpreted as a pseudolymphomatous inflammation or lymphoreticular reaction.