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Influence of thyroid status on hemoglobin A2 expression.

J M Kuhn, M Rieu, J Rochette

    The Journal of Clinical Endocrinology and Metabolism
    |August 1, 1983
    PubMed
    Summary
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    Thyroid hormones influence hemoglobin synthesis. Untreated hyperthyroidism alters hemoglobin A2 and red blood cell indices, which normalize upon treatment, suggesting hormonal modulation of globin chain production.

    Area of Science:

    • Endocrinology
    • Hematology
    • Molecular Biology

    Background:

    • Thyroid hormones play a crucial role in various physiological processes.
    • Alterations in thyroid function are known to affect hematological parameters.
    • The specific impact of hyperthyroidism and hypothyroidism on hemoglobin variants and red blood cell indices requires further elucidation.

    Purpose of the Study:

    • To investigate the electrophoretic patterns of hemoglobin (Hb) and red blood cell indices in women with untreated hyperthyroidism, hypothyroidism, beta-thalassemia trait, and healthy controls.
    • To determine the effect of thyroid status on HbA2 levels and red blood cell indices.
    • To explore the potential role of thyroid hormones in modulating globin chain synthesis.

    Main Methods:

    • Electrophoretic analysis of hemoglobin.

    Related Experiment Videos

  • Measurement of red blood cell indices.
  • Comparison of hematological parameters across four groups of women: nonanemic hyperthyroid, nonanemic hypothyroid, beta-thalassemia trait, and healthy controls.
  • Follow-up assessment after treatment of hyperthyroidism.

    • Main Results:

    • Untreated hyperthyroid women exhibited higher HbA2 levels and lower mean cellular volume compared to euthyroid controls.
    • Hypothyroid women showed lower HbA2 levels and higher mean cellular volume than healthy controls.
    • Fetal hemoglobin was detected in some untreated hyperthyroid patients.
    • Erythrocyte parameters normalized in hyperthyroid patients after achieving euthyroid status.

    Conclusions:

    • Thyroid hormones appear to modulate the synthesis of delta- and gamma-globin chains.
    • Thyroid dysfunction significantly impacts hemoglobin composition and red blood cell indices.
    • These findings highlight the intricate relationship between thyroid function and hematopoiesis.