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Epidermal stem cells.

R M Lavker, T T Sun

    The Journal of Investigative Dermatology
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified two distinct basal keratinocyte populations in monkey palm epidermis. The nonserrated basal cells show characteristics of slow-cycling stem cells, potentially giving rise to transient amplifying cells.

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    Area of Science:

    • Dermatology
    • Cell Biology
    • Stem Cell Research

    Background:

    • Stem cells are crucial for self-renewing tissues, driving cell growth and differentiation.
    • A subpopulation of epidermal basal keratinocytes is hypothesized to be epidermal stem cells, but definitive identification is lacking.

    Purpose of the Study:

    • To investigate the existence and characteristics of potential stem cells within primate epidermis.
    • To explore the roles of distinct basal keratinocyte subpopulations in epidermal renewal.

    Main Methods:

    • Morphological analysis of basal keratinocyte subpopulations in monkey palm epidermis.
    • Spatial segregation analysis of these subpopulations.
    • Tritiated thymidine labeling to assess cell cycling kinetics.

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    Main Results:

    • Two distinct basal keratinocyte subpopulations were identified: serrated (shallow rete ridges) and nonserrated (deep rete ridges).
    • Nonserrated basal keratinocytes exhibited a primitive cytoplasm, abundant melanosomes, and a flattened dermal-epidermal junction.
    • Tritiated thymidine labeling indicated that nonserrated basal cells are slow-cycling, with a highly proliferative keratinocyte population located suprabasally.

    Conclusions:

    • The nonserrated basal keratinocytes in monkey palm epidermis display characteristics consistent with epidermal stem cells.
    • These putative stem cells likely generate transient amplifying cells, which then differentiate terminally.
    • Monkey palm epidermis serves as a valuable model for studying primate epidermal stem cells.