Solvent deposition method for enhancement of dissolution rate: importance of drug-to-excipient ratio
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Updated: Aug 18, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Abstract:
Dissolution rates and particle sizes of phenylbutazone solvent deposited on lactose, starch, and silicon dioxide, separately, and of norethindrone and digoxin deposited on lactose were investigated. Microparticulate dispersed drugs on the surface of excipients result when drug-to-excipient ratios are low. Fast dissolution rates are observed for such systems. This effect can be extended to higher ratios when silicon dioxide is used as the excipient. Because of adsorption, however, the release from silicon dioxide is more or less limited.
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