Related Experiment Videos
[Anti-angiogenesis, a possible new modality of cancer treatment]
Abstract:
During the past decade a number of pioneering knowledge of neovascularization induced by neoplasm have been accumulated and a clinical application of anti-angiogenesis treatment seems to be launched within very near future. While the most Japanese research workers in the medical field are still dreaming of immunological approaches to cancers. But now we should stand on the wide view of basic biology of cancer and open searches for newer attacking targets of cancers. Such a newer modality may be included in biological treatment against not only tumor growth but also invasion, angiogenesis, and metastasis. As an example of a search for newer attacking target of cancer, here I proposed a view point regarding tumor angiogenesis as a symbiotic system of tumor cells and endothelial cells and I reviewed briefly on recent aspects of angiogenesis and anti-angiogenesis, introducing works of Drs. Folkman, Fenselau, Kumar, Weiss, Rifkin, Langer, Eisenstein, Gullino, and others. I hope this short review may attract many more research workers to the "virgin" field of angiogenesis.
Insights
This review explores tumor angiogenesis, a process where tumors create new blood vessels. It highlights anti-angiogenesis treatments as a promising future cancer therapy, moving beyond traditional approaches.
Area of Science:
- Oncology
- Vascular Biology
- Cancer Biology
Context:
- Significant advancements in understanding neoplasm-induced neovascularization (angiogenesis) over the past decade.
- Clinical application of anti-angiogenesis treatments is imminent.
- Current research in Japan predominantly focuses on immunological cancer approaches.
Purpose:
- To broaden the perspective on cancer research by considering basic cancer biology.
- To identify novel therapeutic targets beyond tumor growth, including invasion, angiogenesis, and metastasis.
- To propose tumor angiogenesis as a symbiotic system between tumor cells and endothelial cells.
Summary:
- Reviews recent developments in angiogenesis and anti-angiogenesis research.
- Highlights pioneering work by researchers like Folkman, Fenselau, Kumar, and others.
- Encourages further investigation into the "virgin" field of angiogenesis.
Impact:
- Shifts focus towards biological treatments targeting multiple facets of cancer progression.
- Promotes a systems-biology approach to understanding tumor development.
- Aims to stimulate new research directions in the critical area of tumor angiogenesis and its therapeutic inhibition.