The histamine releasing activity of the industrial agent--Fasavin E4

The effect of an industrial agent--Fasavin E4, on isolated rat mast cells has been investigated. It was shown that Fasavin E4 released histamine in concentration dependent fashion. The reaction was neither calcium nor energy dependent. It is concluded that histamine release induced by Fasavin E4 does not conform to secretion and possibly occurred due to membrane damage by cytolytic process.