Related Experiment Video
Updated: Aug 12, 2026

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
Published on: January 31, 2018
'Metabolic' factors in thermal injury: role of nucleic acids
Abstract:
We believe that toxic events observed after thermal injury may be caused by the release of normally intracellular substances into the circulation. We define these substances as 'metabolic' factors. Analysis of extracts prepared from normal and burned mouse skin indicates that the burned skin extract contains increased clot-promoting (Thromboplastin-like) substances and, perhaps, less RNA than normal skin extracts. Injection of RNA or its breakdown products into the burned site significantly increases the acute mortality in burned mice. No increase in mortality is observed when these substances are injected into a non-burned site on burned mice. We suggest that 'Thromboplastin-like substances and RNA or RNA breakdown products may be some of the 'metabolic' factors involved in acute burn toxicity. Upon being released from their intracellular residence after thermal injury, their combined activity contributes to the acute mortality observed.
Related Concept Videos
Nucleotide Excision Repair
Overview of DNA Repair
Chemically...
Nucleotide Excision Repair
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Diversity of Archaea IV
Cellular Injury I: Introduction
Cellular Injury II: Classification

