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Related Experiment Videos

Intercompartmental fluid shifts after dextran infusion in rabbits.

V Mohsenin, A B DuBois

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |June 1, 1983
    PubMed
    Summary

    Hyperoncotic dextran infusion increased plasma volume in rabbits by drawing fluid from interstitial spaces. This fluid shift did not affect cellular compartments, indicating limited hydrodynamic coupling.

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    Area of Science:

    • Physiology
    • Fluid Dynamics
    • Biomedical Science

    Background:

    • Understanding intercompartmental fluid shifts is crucial for managing fluid balance.
    • Hyperoncotic solutions are used therapeutically, necessitating study of their physiological effects.
    • The interaction between intravascular, interstitial, and cellular fluid compartments requires detailed investigation.

    Purpose of the Study:

    • To investigate intercompartmental fluid shifts following dextran infusion.
    • To determine the impact of hyperoncotic dextran on plasma volume, blood pressure, and fluid pressures.
    • To elucidate the relationship between plasma oncotic pressure and transcapillary fluid movement.

    Main Methods:

    • Infusion of hyperoncotic dextran solution (MW 64,200) in New Zealand White rabbits.
    • Measurement of plasma volume, systemic blood pressure, central venous pressure, and interstitial fluid pressure.
    • Analysis of plasma sodium, chloride, and osmolality before and after dextran administration.

    Main Results:

    • Plasma volume increased significantly by 83 +/- 12 ml.
    • Systemic blood pressure and central venous pressure showed marked increases.
    • Interstitial fluid pressure decreased from -1 to -8 cmH2O.
    • Plasma sodium, chloride, and osmolality remained unchanged post-infusion.

    Conclusions:

    • Increased plasma oncotic pressure induced transcapillary fluid shift into the bloodstream.
    • The interstitial space did not appear to hydrodynamically couple the intravascular space to the cellular compartment.
    • Dextran infusion primarily expanded plasma volume without significant cellular fluid shifts.

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