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Involvement of post-capillary venules in Behçet's disease: an electronmicroscopic study.
Acta Dermato-Venereologica
|January 1, 1983
Summary
Behçet's disease involves severe changes in post-capillary venules. Initial pathology may include thickening of the basal lamina around these small veins.
Area of Science:
- Vascular Biology
- Pathology
- Rheumatology
Background:
- Behçet's disease is a multisystem inflammatory disorder.
- Pathological changes are prominent in the vasculature, particularly venules.
Observation:
- Severe pathological alterations are noted in post-capillary venules.
- This suggests significant involvement of the venous circulation.
Findings:
- A proposed initial pathological event is the multiplication of the basal lamina.
- This thickening occurs in the wall of post-capillary venules.
Implications:
- Understanding early venous changes may reveal novel therapeutic targets.
- This finding could refine diagnostic criteria for Behçet's disease.