Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intratumor immunologic heterogeneity.

F R Miller

    Cancer Metastasis Reviews
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Tumor cells exhibit significant immunologic heterogeneity, with varying antigen expression across subpopulations. Understanding this diversity is key to developing novel cancer immunotherapies targeting tumor cells effectively.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetics of nonsenescence and charcoal rot resistance in sorghum.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
    Same author

    Cellular changes produced by extracts of human organs.

    Blood·2010
    Same author

    Conjugated forms of myelokentric and lymphokentric acids.

    The Journal of biological chemistry·2010
    Same author

    The treatment of lymphoblastic leukemia with crude myelokentric acid.

    Transactions & studies of the College of Physicians of Philadelphia·2010
    Same author

    RECENT ADVANCES IN THE PHYSIOLOGY OF THE CAPILLARY CIRCULATION.

    Canadian Medical Association journal·2010
    Same author

    Varied Operations.

    Canadian Medical Association journal·2010
    Same journal

    HER2 assessment in urothelial carcinoma: standardization challenges and the path forward.

    Cancer metastasis reviews·2026
    Same journal

    Resolving translational challenges in cancer biology through yeast experimental evolution.

    Cancer metastasis reviews·2026
    Same journal

    Spheroids and organoids to study long noncoding RNAs in cancer: how they could replace animal models.

    Cancer metastasis reviews·2026
    Same journal

    Strategies and successes of smoking cessation methods in head and neck cancer patients: a systematic review.

    Cancer metastasis reviews·2026
    Same journal

    The Hippo signaling pathway in pediatric brain tumors: molecular mechanisms and therapeutic opportunities.

    Cancer metastasis reviews·2026
    Same journal

    Antibody-drug conjugates in breast cancer brain and leptomeningeal metastases: mechanistic insights and therapeutic progress.

    Cancer metastasis reviews·2026
    See all related articles

    Area of Science:

    • Oncology
    • Immunology
    • Cancer Research

    Background:

    • Tumor cells express diverse antigens, including tumor-specific transplantation antigens and tumor-associated antigens.
    • Antigen distribution is uneven across tumor subpopulations, leading to varied immune responses.
    • Intratumor immunologic heterogeneity emerges early in cancer and persists throughout progression.

    Purpose of the Study:

    • To investigate the nature and implications of immunologic heterogeneity in tumor cells.
    • To explore how antigen diversity influences immune responses within tumors.
    • To identify potential therapeutic strategies based on tumor immunologic heterogeneity.

    Main Methods:

    • Analysis of antigen expression patterns on different tumor subpopulations.

    Related Experiment Videos

  • Evaluation of immune responses elicited by individual and co-existing tumor subpopulations.
  • Examination of mechanisms underlying antigenic cross-reactivity between subpopulations.

    • Main Results:

    • Tumor subpopulations display distinct arrays of antigenic determinants and variable cell surface expression.
    • Antigenic cross-reactions between subpopulations are common, influenced by factors like quantitative differences and cell-cycle variations.
    • Interactions between co-existing subpopulations can modulate overall immune responses.

    Conclusions:

    • Exploiting tumor immunologic heterogeneity offers promising avenues for novel cancer therapies.
    • The diversity of tumor cell determinants supports the development of multivalent monoclonal antisera for targeted tumor cell lysis.