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Related Experiment Videos

Cerebrospinal fluid myelin basic protein in hydrocephalus.

L N Sutton, J H Wood, B R Brooks

    Journal of Neurosurgery
    |September 1, 1983
    PubMed
    Summary

    Active hydrocephalus is linked to increased myelin basic protein (MBP) in cerebrospinal fluid (CSF), indicating demyelination. Ventricular size correlates with MBP levels, suggesting mechanical stretching causes this damage.

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    Area of Science:

    • Neuroscience
    • Neurology
    • Biochemistry

    Background:

    • Hydrocephalus is a condition characterized by abnormal accumulation of cerebrospinal fluid (CSF) within the brain's ventricles.
    • Myelin basic protein (MBP) is a key component of myelin, the protective sheath around nerve fibers.
    • Elevated MBP in CSF is a potential biomarker for demyelination in various neurological disorders.

    Purpose of the Study:

    • To investigate the relationship between active hydrocephalus and immunoreactive myelin basic protein (MBP) levels in CSF.
    • To determine if MBP levels correlate with hydrocephalus severity, etiology, and ventricular size.

    Main Methods:

    • Cerebrospinal fluid (CSF) samples were collected from 57 patients with active hydrocephalus.
    • Immunoreactive MBP levels were quantified using established assays.

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  • Ventricular size was assessed using computerized tomography (CT) scans, calculating the ventricle-to-brain ratio.

    • Main Results:

    • 49% of patients with active hydrocephalus exhibited elevated MBP levels (>4.5 ng/ml).
    • Elevated MBP was observed in 44% (congenital) to 83% (porencephaly) of hydrocephalus subtypes.
    • A significant correlation was found between ventricular size and MBP levels (p<0.05), with larger ventricles showing higher MBP concentrations, except in maximal hydrocephalus possibly due to dilution.

    Conclusions:

    • Active hydrocephalus is associated with significant periventricular demyelination.
    • Mechanical stretching of brain tissue is a probable cause of this demyelination.
    • MBP in CSF may serve as a biomarker for active demyelination in hydrocephalus.