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[The HLA-DR determinants in chronic inflammatory rheumatism]
Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|June 1, 1983
Summary
The study found a higher incidence of the HLA-DR4 antigen in rheumatoid arthritis patients and a lower incidence of the HLA-DR2 antigen, suggesting a protective role for DR2 in drug intolerance.
Area of Science:
- Immunogenetics
- Rheumatology
Context:
- Investigating the genetic factors associated with chronic inflammatory rheumatism.
- Examining the Breton population for specific Human Leukocyte Antigen - Antigen D Related (HLA-DR) profiles.
Purpose:
- To determine the incidence of HLA-DR antigens in patients with chronic inflammatory rheumatism, specifically rheumatoid arthritis.
- To explore the association between HLA-DR antigen profiles and drug intolerance in patients with chronic inflammatory rheumatism.
Summary:
- A study of 113 controls and Breton patients with chronic inflammatory rheumatism found a significant increase in HLA-DR4 antigen incidence (54% vs. 19.5%) in 80 rheumatoid arthritis cases.
- A decreased incidence of HLA-DR2 antigen was observed in rheumatoid arthritis (12.5% vs. 35%) and in patients experiencing drug intolerance (cutaneous/renal to gold salts or D-penicillamine).
- The increased HLA-DR4 incidence in rheumatoid arthritis was independent of rheumatoid factor, while the decreased HLA-DR2 incidence in drug intolerance suggests a protective role.
Impact:
- Highlights the potential genetic predisposition to rheumatoid arthritis through specific HLA-DR antigens.
- Provides evidence for a protective effect of the HLA-DR2 antigen against drug intolerance in patients with chronic inflammatory rheumatism.
- Informs future research on HLA-DR antigen associations with autoimmune diseases and adverse drug reactions.