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The interferons.

J L Toy

    Clinical and Experimental Immunology
    |October 1, 1983
    PubMed
    Summary

    Interferons are proteins with crucial roles in immunity and fighting infections. This overview covers their genes, structure, actions, and clinical uses in cancer and viral diseases, including in patients with acquired immunodeficiency syndrome (AIDS).

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    Area of Science:

    • Immunology
    • Molecular Biology
    • Virology
    • Oncology

    Background:

    • Interferons (IFNs) are a group of signaling proteins made and released by host cells of the immune system in response to the presence of several pathogens.
    • They play a vital role in the innate immune system's response to viral infections and in modulating the adaptive immune response.

    Purpose of the Study:

    • To provide a comprehensive overview of interferons.
    • To detail their genetic basis, protein characteristics, and mechanisms of action.
    • To highlight their diverse biological and immunomodulatory effects, and summarize current clinical applications.

    Main Methods:

    • Literature review and synthesis of existing knowledge on interferons.
    • Analysis of data from human clinical studies in oncology and virology.
    • Inclusion of recent findings related to acquired immunodeficiency syndrome (AIDS).

    Main Results:

    • Interferons exhibit varied biological effects, with a strong emphasis on immunomodulatory actions.
    • Clinical studies demonstrate the utility of interferons in treating oncological and viral diseases.
    • Emerging data show relevance in managing conditions like AIDS.

    Conclusions:

    • Interferons are critical components of the immune system with significant therapeutic potential.
    • Ongoing research continues to expand our understanding and application of interferons in medicine.
    • Interferon therapy shows promise in managing complex diseases such as cancer, viral infections, and AIDS.

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