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Updated: Aug 14, 2026

Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections
Published on: November 14, 2016
Comparison of antigens in the rat MHC that act as CML determinants
Abstract:
We have examined a variety of RT1 haplotypes using congenic strains of rats to investigate the comparative relationships among MHC antigens that have been reported to serve as cell-mediated lympholysis (CML) targets. These studies demonstrate that: (1) RT1.A antigens can act as CML determinants, and in some haplotypes they display identical serological and CML reaction patterns; (2) in some donor-recipient strain combinations RT1.A antigens may act as immunodominant determinants, preventing the generation of effectors capable of recognizing other antigens, and (3) a portion of the antigenic determinants that define the anti-CT CML response can be mapped to the same region of the rat MHC as the RT1.E locus.
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