Related Experiment Videos
Symmetry of effector function in the immune system network
Symmetry in antibody plus complement mediated killing between a T15 idiotype-bearing monoclonal antibody (HPC-M2) and an anti-T15 monoclonal antibody (B36-82) is demonstrated. The HPC-M2 antibody is also shown to be multispecific in its effector function, since it lyses both phosphorylcholine coated erythrocytes, and B36-82 Fab coated red blood cells. The symmetry and multispecificity in effector function are presented as new evidence against the concept that the paratope of antibody molecule exists as a uniquely defined site on the antibody variable region. A theoretical consequence for immune system network theory is that the anti-idiotypic set and the internal image are functionally equivalent, the results support symmetric network models of regulation, and are evidence against asymmetric models.
Symmetry in antibody plus complement mediated killing between a T15 idiotype-bearing monoclonal antibody (HPC-M2) and an anti-T15 monoclonal antibody (B36-82) is demonstrated. The HPC-M2 antibody is also shown to be multispecific in its effector function, since it lyses both phosphorylcholine coated erythrocytes, and B36-82 Fab coated red blood cells. The symmetry and multispecificity in effector function are presented as new evidence against the concept that the paratope of antibody molecule exists as a uniquely defined site on the antibody variable region. A theoretical consequence for immune system network theory is that the anti-idiotypic set and the internal image are functionally equivalent, the results support symmetric network models of regulation, and are evidence against asymmetric models.