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Lignocaine test and detrusor instability.

K Reuther, J Aagaard, K S Jensen

    British Journal of Urology
    |October 1, 1983
    PubMed
    Summary
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    Intravesical lignocaine can differentiate detrusor instability caused by bladder outlet obstruction from idiopathic cases. A positive lignocaine test predicts resolution of detrusor instability after surgery.

    Area of Science:

    • Urology
    • Nephrology
    • Clinical Pharmacology

    Background:

    • Detrusor instability is common in infravesical obstruction and often resolves post-surgery.
    • The exact cause of detrusor instability is unknown but may involve heightened bladder sensory input.
    • Intravesical lignocaine has shown a temporary effect on detrusor instability.

    Purpose of the Study:

    • To differentiate idiopathic detrusor instability from that caused by infravesical obstruction.
    • To assess the predictive value of intravesical lignocaine testing pre-operatively.

    Main Methods:

    • A study involving patients with detrusor instability.
    • Administration of intravesical lignocaine to assess bladder sensory input.
    • Correlation of lignocaine test results with post-operative outcomes.

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    Main Results:

    • Patients with a positive pre-operative lignocaine test experienced resolution of detrusor instability and micturition disorders after surgery.
    • Patients with a negative pre-operative lignocaine test showed persistent detrusor instability post-surgery.
    • The observed differences between the groups were statistically significant (P < 0.5).

    Conclusions:

    • Intravesical lignocaine testing is a valuable tool for differentiating the etiology of detrusor instability.
    • A positive lignocaine test predicts successful surgical outcomes for infravesical obstruction-related detrusor instability.